Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (9): 1369-1370.doi: 10.4103/1673-5374.165498

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The choline pathway as a strategy to promote central nervous system (CNS) remyelination

Thomas Skripuletz, Ralf A. Linker, Martin Stangel   

  1. Department of Neurology, Hannover Medical School, Hannover, Germany (Skripuletz T, Stangel M)
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany (Linker RA)
    Center for Systems Neuroscience, Hannover, Germany (Stangel M)
  • Received:2015-07-27 Online:2015-09-28 Published:2015-09-28
  • Contact: Martin Stangel, M.D., Stangel.Martin@MH-Hannover.de.

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Abstract:

The choline pathway as a strategy to promote CNS remyelination
CDP-choline showed repair promoting functions in two animal models of multiple sclerosis with a new mechanism of action. Due to the known beneficial safety profile, CDP-choline may be a promising substance for patients with multiple sclerosis, which is worth further investigations e.g., as add-on therapy to established immunmodulators.