Abstract:

Additionally, our data emphasize the delicate balance of inflammation leading either to neurodegeneration or neuroprotection. Current therapeutic strategies for MS aim at suppressing CNS inflammation and enhancing neuroprotection. Therefore, molecular and cellular insights obtained in rodent MS models, highlighting the importance of the neuronal compartment for disease progression, might prove useful for the understanding of mechanisms involved in the onset of human MS disease. Finally, the investigation of neuronal signaling mechanisms, such as SRF mediated gene transcription, identified in MS mouse models, might provide new valuable molecular targets relevant to human MS therapy.