Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (10): 1678-1682.doi: 10.4103/1673-5374.167769

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Inflammation and cutaneous nervous system involvement in hypertrophic scarring

Shao-hua Li1, Heng-lian Yang2, Hu Xiao1, *, Yi-bing Wang1, De-chang Wang1, Ran Huo1   

  1. 1 Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China
    2 Jinan Fire Protection Hospital, Jinan, Shandong Province, China
  • Received:2015-06-15 Online:2015-10-28 Published:2015-10-28
  • Contact: Hu Xiao, Ph.D., 847247374@qq.com.
  • Supported by:

    This study was supported by a grant from the Development of Medical Science and Technology Project of Shandong Province in China, No. 2014WS0354; the National Natural Science Foundation of China, No. 81272099; the Shandong Medical and Health Science and Technology Development Program Fund for Youth in China, No. 2009QZ023; and the Natural Science Foundation of Shandong Province in China, No. BS2009YY043.

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Abstract:

This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.

Key words: nerve regeneration, peripheral nerve regeneration, hypertrophic scar, interleukin-13, wound healing, nerve growth factor, neural regeneration