Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (1): 28-31.doi: 10.4103/1673-5374.169602

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Direct reprogramming of somatic cells into neural stem cells or neurons for neurological disorders

Shaoping Hou 1, Paul Lu 2, 3   

  1. 1 Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
    2 Veterans Administration Medical Center, San Diego, CA, USA
    3 Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA
  • Online:2016-01-15 Published:2016-01-15
  • Contact: Paul Lu, Ph.D., plu@ucsd.edu.
  • Supported by:

    This work was supported by the Veterans Administration, the Craig H. Neilsen Foundation (280072 to SH), the California Institute for Regenerative Medicine.

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Abstract:

Direct reprogramming of somatic cells into neurons or neural stem cells is one of the most important frontier
fields in current neuroscience research. Without undergoing the pluripotency stage, induced neurons or induced neural stem cells are a safer and timelier manner resource in comparison to those derived from induced pluripotent stem cells. In this prospective, we review the recent advances in generation of induced neurons and induced neural stem cells in vitro and in vivo and their potential treatments of neurological disorders.

Key words: neural cells, induced neural stem cells, induced neurons, pluripotent stem cells, neurological diseases