Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (1): 150-155.doi: 10.4103/1673-5374.175062

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A novel bioactive nerve conduit for the repair of peripheral nerve injury

Bin-bin Li 1, 2, Yi-xia Yin 1, 2,Qiong-jiao Yan 1, 2, Xin-yu Wang 1, 2, Shi-pu Li 1, 2   

  1. 1 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, Hubei Province, China
    2 Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan, Hubei Province, China
  • Received:2015-12-16 Online:2016-01-15 Published:2016-01-15
  • Contact: Yi-xia Yin,yinyixia@whut.edu.cn.
  • Supported by:

    This study was supported by a grant from the National Key Basic Research Program of China, No. 2011CB606205; a grant from the National Natural Science Foundation of China, No. 51403168; a grant from the Major Scientific and Technological Research Projects of the Ministry of Education of China, No. 313041; and a grant from the Scientific and Technological Cooperation Projects of Hong Kong, Macao and Taiwan, China, No. 2015DFH30180.

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Abstract:

The use of a nerve conduit provides an opportunity to regulate cytokines, growth factors and neurotrophins in peripheral nerve regeneration
and avoid autograft defects. We constructed a poly-D-L-lactide (PDLLA)-based nerve conduit that was modified using poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]} and β-tricalcium phosphate. The effectiveness of this bioactive PDLLA-based nerve conduit was compared to that of PDLLA-only conduit in the nerve regeneration following a 10-mm sciatic nerve injury in rats. We observed the nerve morphology in the early period of regeneration, 35 days post injury, using hematoxylin-eosin and methylene blue staining. Compared with the PDLLA conduit, the nerve fibers in the PDLLA-based bioactive nerve conduit were thicker and more regular in size. Muscle fibers in the soleus muscle had greater diameters in the PDLLA bioactive group than in the PDLLA only group. The PDLLA-based bioactive nerve conduit is a promising strategy for repair after sciatic nerve injury.