Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (4): 623-629.doi: 10.4103/1673-5374.180748

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Neuroprotective effect of Cerebralcare Granule after cerebral ischemia/reperfusion injury

Xiao-xiao Zhang1, 2, Fen-fen He1, 2, Gui-lin Yan1, Ha-ni Li2, Dan Li1, Yan-ling Ma1, Fang Wang1, Nan Xu1, Fei Cao1, *   

  1. 1 Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    2 Department of Neurology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • Received:2016-01-07 Online:2016-04-30 Published:2016-04-30
  • Contact: Fei Cao, caofyx@163.com.
  • Supported by:

    This study was supported by a grant from the Tasly Pharmaceutical Co., Ltd. in Tianjin and the Ministry of Science and Technology in Wuhan, Hubei Province, China, No. 2013060602010234.

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Abstract:

Cerebralcare Granule (CG) improves cerebral microcirculation and relieves vasospasm, but studies investigating its therapeutic effect on
cerebral ischemia/reperfusion injury are lacking. In the present study, we administered CG (0.3, 0.1 and 0.03 g/mL intragastrically) to rats
for 7 consecutive days. We then performed transient occlusion of the middle cerebral artery, followed by reperfusion, and administered CG
daily for a further 3 or 7 days. Compared with no treatment, high-dose CG markedly improved neurological function assessed using the
Bederson and Garcia scales. At 3 days, animals in the high-dose CG group had smaller infarct volumes, greater interleukin-10 expression,
and fewer interleukin-1β-immunoreactive cells than those in the untreated model group. Furthermore, at 7 days, high-dose CG-treated
rats had more vascular endothelial growth factor-immunoreactive cells, elevated angiopoietin-1 and vascular endothelial growth factor expression,
and improved blood coagulation and flow indices compared with untreated model animals. These results suggest that CG exerts
specific neuroprotective effects against cerebral ischemia/reperfusion injury.

Key words: nerve regeneration, Cerebralcare Granule, cerebral ischemia/reperfusion, angiogenesis, inflammatory response, blood coagulation, hemorheology, neural regeneration