Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (5): 816-822.doi: 10.4103/1673-5374.182710

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Repetitive magnetic stimulation affects the microenvironment of nerve regeneration and evoked potentials after spinal cord injury

Jin-lan Jiang1, 2, #, Xu-dong Guo3, Shu-quan Zhang4, Xin-gang Wang5, Shi-feng Wu5, *, #   

  1. "1 Scientific Research Center, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China 2 Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China 3 Department of Cardiovascular Medicine, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China 4 Department of Orthopedics, Tianjin Nankai Hospital, Tianjin, China 5 Department of Burns and Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China"
  • Received:2016-01-26 Online:2016-05-20 Published:2016-05-20
  • Contact: Shi-feng Wu, wsf19770620@126.com.

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Abstract:

"Repetitive magnetic stimulation has been shown to alter local blood flow of the brain, excite the corticospinal tract and muscle, and induce motor function recovery. We established a rat model of acute spinal cord injury using the modified Allen’s method. After 4 hours of injury, rat models received repetitive magnetic stimulation, with a stimulus intensity of 35% maximum output intensity, 5-Hz frequency, 5 seconds for each sequence, and an interval of 2 minutes. This was repeated for a total of 10 sequences, once a day, 5 days in a week, for 2 consecutive weeks. After repetitive magnetic stimulation, the number of apoptotic cells decreased, matrix metalloproteinase 9/2 gene and protein expression decreased, nestin expression increased, somatosensory and motor-evoked potentials recovered, and motor function recovered in the injured spinal cord. These findings confirm that repetitive magnetic stimulation of the spinal cord improved the microenvironment of neural regeneration, reduced neuronal apoptosis, and induced neuroprotective and repair effects on the injured spinal cord."

Key words: "nerve regeneration, spinal cord injury, repetitive magnetic stimulation, motor function, rats, rehabilitation, plasticity, regenerative microenvironment, neural regeneration"