Abstract: There is currently no treatment for effectively slowing the progression of Alzheimer’s disease, so early prevention is very important. Numerous studies have shown that ?avonoids can improve memory impairment. Te present study investigated the effects of myricetin, a member of the ?avonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer’s disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer’s disease. Tese fndings suggest that myricetin is benefcial for treatment of Alzheimer’s disease.

Key words: nerve regeneration, myricetin, Alzheimer’s disease, streptozotocin, hippocampus, pyramidal neurons, CA3 region, behavioral test, neural regeneration