Abstract: Magnesium (Mg) wire has been shown to be biodegradable and have anti-in?ammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons afer central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. Te numbers of cross section nerve fbers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immuno?uorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve afer Mg treatment. Our fndings confrm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.

Key words: nerve regeneration, peripheral nerve regeneration, biodegradable, magnesium wire, sciatic nerve, rats, nerve growth factor, P75 neurotrophin receptor, tyrosine receptor kinase A, neural regeneration