Neural Regeneration Research ›› 2017, Vol. 12 ›› Issue (7): 1028-1035.doi: 10.4103/1673-5374.211174

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Impact of glucocorticoid on neurogenesis

Haruki Odaka1, 2, Naoki Adachi3, 4, Tadahiro Numakawa2, 4   

  1. 1 Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan; 2 Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan; 3 Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan; 4 Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan
  • Received:2017-07-07 Online:2017-07-15 Published:2017-07-15
  • Contact: Tadahiro Numakawa, Ph.D., numakawa.yyrmk@gmail.com.
  • Supported by:

    This study was supported by grants from by Takeda Science Foundation (TN, NA), and from the Grant-in-Aid for Scientific Research(C) (JSPS KAKENHI JP16K06996) (to TN) and JSPS KAKENHI Grant Number 17J04183 (to HO) in the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Abstract:

Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to brain diseases, including mental disorders and neurodevelopmental disease. Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors. Moreover, proliferation/differentiation of the neural stem/progenitor cells (NSPCs) is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt, hedgehog, and Wnt. Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms; this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases.

Key words: neural progenitor cells, glucocorticoids, neurogenesis, intracellular signaling pathways