Neural Regeneration Research ›› 2017, Vol. 12 ›› Issue (11): 1918-1926.doi: 10.4103/1673-5374.219055

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Research on human glioma stem cells in China

Yao-dong Zhao1, 2, Quan-bin Zhang1, 3, Hua Chen1, 4, Xi-feng Fei1, 5, Yun-tian Shen1, Xiao-yan Ji1, Jia-wei Ma1, Ai-dong Wang1, Jun Dong1, Qing Lan1, Qiang Huang1   

  1. 1 Department of Neurosurgery and Brain Tumor Research Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province,China
    2 Shanghai General Hospital, Shanghai, China
    3 Shanghai 10th People’s Hospital, Shanghai, China
    4 Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
    5 Suzhou Kowloon Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • Received:2017-07-31 Online:2017-11-15 Published:2017-11-15
  • Contact: Qiang Huang, M.D.,hq1936@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81172400, 81101909, 81272793, 81302180,81302196, 81472739.

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Abstract:

Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signaling pathways, cancer treatment, the stem cell microenvironment and the cellular origin and function of glioma stem cells. In particular, we put forward our view that there are inverse or forward transformations among neural stem cells, glial cells and glioma stem cells in glioma tissues under certain conditions. Based on the background of the progress of international research on human glioma stem cells, we aim to share our progress and current findings of human glioma stem cell research in China with colleagues around the world.

Key words: nerve regeneration, glioma stem cells, China, cell culture, molecular characteristics, cellular origin, cell function, microenvironment, molecular targeted therapy, chemotherapy, radiotherapy, neural regeneration