Neural Regeneration Research ›› 2017, Vol. 12 ›› Issue (12): 2106-2112.doi: 10.4103/1673-5374.221171

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Roles of neural stem cells in the repair of peripheral nerve injury.

Chong Wang1, 2, 3, Chang-feng Lu2, 3, Jiang Peng2, 3, 4, 5, Cheng-dong Hu1, Yu Wang2, 3, 4, 5   

  1. 1 Central Hospital of Handan, Handan, Hebei Province, China
    2 Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China
    3 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
    4 Beijing Key Lab of Regenerative Medicine in Orthopedics, Beijing, China
    5 Key Lab of Musculoskeletal Trauma & War Injuries of Chinese PLA, Beijing, China
  • Received:2017-10-09 Online:2017-12-15 Published:2017-12-15
  • Contact: Yu Wang, M.D. or Cheng-dong Hu,wangwangdian628@126.com or hcd111111@163.com.
  • Supported by:

    This study was supported by the Major State Basic Research and Development Program of China (973 Program), No. 2014CB542201;the National Key Research and Development Program of China, No. 2016YFC1101601, 2017YFA0104702; the Natural Science Foundation of Beijing of China, No. 7172202; a grant from the 13th Five-Year Plan Period of People’s Liberation Army of China, No. BWS13C029-5; a grant from the Science and Technology Project of Beijing of China, No. Z161100005016059.

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Abstract:

Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. This article reviews recent research progress of the role of neural stem cells in the repair of peripheral nerve injury.Neural stem cells can not only differentiate into neurons, astrocytes and oligodendrocytes, but can also differentiate into Schwann-like cells, which promote neurite outgrowth around the injury. Transplanted neural stem cells can differentiate into motor neurons that innervate muscles and promote the recovery of neurological function. To promote the repair of peripheral nerve injury, neural stem cells secrete various neurotrophic factors, including brain-derived neurotrophic factor, fibroblast growth factor, nerve growth factor, insulin-like growth factor and hepatocyte growth factor. In addition, neural stem cells also promote regeneration of the axonal myelin sheath, angiogenesis, and immune regulation. It can be concluded that neural stem cells promote the repair of peripheral nerve injury through a variety of ways.

Key words: nerve regeneration, neural stem cells, peripheral nerve, regeneration, Schwann-like cells, neurons, neurotrophic factors, neuroprotection, axons, angiogenesis, immune regulation, neural regeneration