Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (3): 410-412.doi: 10.4103/1673-5374.228716

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Linking axon transport to regeneration using in vitro laser axotomy

Bart Nieuwenhuis1, 2, Richard Eva1   

  1. 1 John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    2 Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands
  • Received:2018-02-05 Online:2018-03-15 Published:2018-03-15
  • Contact: Richard Eva, Ph.D., re263@cam.ac.uk.
  • Supported by:

    The study was funded by grants from the Christopher and Dana Reeve Foundation [JFC-2013(3), JFC-2013(4)], the Medical Research Council (G1000864 018556), the International Spinal Research Trust (Nathalie Rose Barr studentship NRB110), ERANET NEURON grant AxonRepair (013-16-002).

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Abstract:

Spinal cord injury has devastating consequences because adult central nervous system (CNS) neurons do not regenerate their axons after injury. Two key reasons for axon regeneration failure are extrinsic inhibitory factors and a low intrinsic capacity for axon regrowth. Research has therefore focused on overcoming extrinsic growth inhibition, and enhancing intrinsic regeneration capacity. Both of these issues will need to be addressed to enable optimal repair of the injured spinal cord.