Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (3): 492-496.doi: 10.4103/1673-5374.228733

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Neuroprotective effect of ischemic postconditioning on sciatic nerve transection

Xiao-bin Zhou1, 2, Na Liu3, Dong Wang1, De-xin Zou4, Chang-wei Wei5, Jun-lin Zhou1   

  1. 1 Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    2 Department of Traumatic Orthopedics, the Third Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China
    3 Department of Internal Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
    4 Department of Spine Surgery, Yan Tai-Shan Hospital, Yantai, Shandong Province, China
    5 Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
  • Received:2018-01-23 Online:2018-03-15 Published:2018-03-15
  • Contact: Jun-lin Zhou, M.D.,junlinzhouvip@sina.com
  • Supported by:

    This work was supported by the 2016 Beijing Municipal Natural Science Foundation (CN), No. 71520061; Beijing Municipal Science and Technology Commission, China, No. Z161100000116080

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Abstract:

Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.

Key words: nerve regeneration, ischemic postconditioning, nerve injury, insulin-like growth factor 1, sciatic nerve, ischemia/reperfusion, neural regeneration