Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (4): 637-638.doi: 10.4103/1673-5374.230284

Previous Articles     Next Articles

Fluorescence detection of Europium-doped very small superparamagnetic iron oxide nanoparticles in murine hippocampal slice cultures

Martin Pohland1, Yuske Kobayashi2, Jana Glumm1, 3   

  1. 1 Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité -Universitätsmedizin Berlin, Berlin, Germany;
    2 Department of Interventional and Diagnostic Radiology and Nuclear Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;
    3 Department of Neurosurgery, HELIOS Klinikum Berlin Buch, Berlin, Germany
  • Received:2018-03-07 Online:2018-04-15 Published:2018-04-15
  • Contact: Jana Glumm, Ph.D., jana.glumm@charite.de
  • Supported by:

    This study was supported by deutsche Forschungsgemeinschaft Grant Klinische Forschungsgruppe 213 to JG.

PDF

261

Abstract:

In the late 1980s, superparamagnetic iron oxide nanoparticles (SPIO) moved into focus as contrast agents in magnetic resonance imaging (MRI), due to their strong relaxivity and resulting higher resolution of images. At the time, no one anticipated their high potential in basic research or for medical diagnostic and treatment. Since then, SPIO have been evaluated not only as specific markers for MRI, but also for cell labeling and tracking . In addition, SPIO are being investigated as carriers for targeted administration of therapeutics, e.g., drugs or gene sequences , in cancer treatment via magnetic hyperthermia and in neuronal regeneration.