Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (9): 1546-1547.doi: 10.4103/1673-5374.237114

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Cerebrospinal fluid and neural stem cell niche control

Mª Isabel Alonso1, 2, Angel Gato1, 2   

  1. 1 Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain;
    2 Laboratorio de Desarrollo y Teratología del Sistema Nervioso, Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Valladolid, Valladolid, Spain
  • Received:2018-06-08 Online:2018-09-15 Published:2018-09-15
  • Contact: Angel Gato, M.D., gato@med.uva.es.

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Abstract:

Neurogenesis from inner brain neural stem cells (NSCs) is a process which takes place continuously in mammals throughout their life. However, the main ontogenic difference is the intensity of neurogenesis, which commences as a very intensive and global activity in the early embryonic brain (neural tube), persists in fetal and newborn stages, and declines significantly in adulthood, becoming restricted to specific places with low neurogenic activity such as the subventricular zone (SVZ) and the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus.