Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (9): 1548-1549.doi: 10.4103/1673-5374.237115

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Regulation of neural stem cell fate decisions by mitochondrial dynamics

Matthew Laaper1, Arezu Jahani-Asl1, 2   

  1. 1 Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada;
    2 Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
  • Received:2018-06-08 Online:2018-09-15 Published:2018-09-15
  • Contact: Arezu Jahani-Asl, Ph.D., MSc, arezu.jahani@mcgill.ca.
  • Supported by:

    AJ-A is a Fonds de recherche du Québec - Santé (FRQS) scholar and supported by a grant from Natural Sciences and Engineering Research Council of Canada (NSERC RGPIN-2016-06605).

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Abstract:

Stem cells possess the ability to divide symmetrically or asymmetrically to allow for maintenance of the stem cell pool or become committed progenitors and differentiate into various cell lineages.The unique self-renewal capabilities and pluripotency of stem cells are integral to tissue regeneration and repair . Multiple mechanisms including intracellular programs and extrinsic cues are reported to regulate neural stem cell (NSC) fate. A recent study, published in Cell Stem Cell, identified a novel mechanism whereby mitochondrial dynamics drive NSC fate.