Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (11): 1887-1889.doi: 10.4103/1673-5374.238614

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Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases

Basant K. Puri1, Gerwyn Morris2   

  1. 1 Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK;
    2 IMPACT Strategic Research Centre, School of Medicine,Deakin University, Geelong, Australia
  • Received:2018-07-16 Online:2018-11-15 Published:2018-11-15
  • Contact: Basant K. Puri, MA, PhD, MB, BChir,MSc, MMath, FRCPsych, FRSB, basant.puri@imperial.ac.uk.

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Abstract:

In 1945, Porter et al. published an electon microscopy study of cultured chick fibroblasts in which they observed: ‘a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of “vesicles”’ . This constituted the first published observation of the endoplasmic reticulum (ER) and, while it was not evident at that time, this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.