Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (1): 51-58.doi: 10.4103/1673-5374.243701

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Tissue engineering for the repair of peripheral nerve injury

Pei-Xun Zhang1, Na Han1, Yu-Hui Kou1, Qing-Tang Zhu2, Xiao-Lin Liu2, Da-Ping Quan2, Jian-Guo Chen3, Bao-Guo Jiang1   

  1. 1 Peking University People’s Hospital, Beijing, China;
    2 The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China;
    3 School of Life Science, Peking University, Beijing, China
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Bao-Guo Jiang, MD, PhD, jiangbaoguo@vip.sina.com; Na Han, PhD, 876804705@qq.com
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 31040043, 31671248 (to NH), No. 81171146, 81372044, 30971526 (to BGJ); the Chinese National Ministry of Science and Technology (973 Project), No. 2014CB542201 (to PXZ); the Min-istry of Education Innovation Team, China, No. IRT1201 (to PXZ); the Fostering Young Scholars of Peking University Health Science Center, China, No. BMU2017PY013 (to PXZ); the Chinese National General Program of National Natural Science Fund, China (to PXZ); the Beijing City Science & Technology New Star Cross Project, China, No. 2018019 (to PXZ); the National Natural Science Foundation of China, No. 31771322, 31571235, 51373023, 21171019, 31640045, 31571236, 31471144, 31100860, 31371210 (to PXZ).

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Abstract:

Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold material, the seed cells and various growth factors. Understanding the type of nerve injury, the construction of scaffold and the process of repair are necessary to solve peripheral nerve injury and promote its regeneration. This review describes the categories of peripheral nerve injury, fundamental research of peripheral nervous tissue engineering and clinical research on peripheral nerve scaffold material, and paves a way for related research and the use of conduits in clinical practice.

Key words: nerve regeneration, scaffold, biomaterial, stem cells, nerve growth factor, peripheral nerve injury, peripheral nerve repair, tissue engineering, neural regeneration