Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (1): 59-61.doi: 10.4103/1673-5374.243703

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Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus

E Francesca Antonelli, Arianna Casciati, Simonetta Pazzaglia   

  1. Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l’Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Simonetta Pazzaglia, PhD, simonetta.pazzaglia@enea.it.
  • Supported by:

    This work was partially supported by grant 15234 from the Associazione Italiana per la Ricerca sul Cancro (AIRC).

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Abstract:

The morphogen Sonic Hedgehog (Shh) plays a critical role in the development of different tissues, both in invertebrates and vertebrates. Shh mediates its action via a receptor com-plex associating two transmembrane proteins: Patched1 (Ptch1) and Smoothened (Smo). The repression exerted by Ptch1 on Smo is relieved when Shh, the ligand, binds to Ptch1, which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally, to the activation of targeted genes including Ptch1 and Gli them-selves.