Abstract:

Ischemic stroke and irreversible consequences: Ischemic stroke in humans is the second most common cause of death in the world. The outcomes after a stroke are often dependent on complications, including motor disorders, depression and dementia, which causes a high risk of re-hospitalization and/or palliative care. This is also the main reason for long-term disability in people after stroke, with up to half of those who survived the stroke will not regain their independence until the end of their lives. According to epidemiological forecasts, human ischemic stroke will soon become the dominant cause of death worldwide as well as dementia with the phenotype of Alzheimer’s disease. It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology. Epidemiological observations have shown that brain ischemia is a contributing factor to the development of AD and vice versa. Below we present the latest advances in the investigation of brain ischemia-reperfusion injury, focusing on ischemia-induced of the AD phenotype and genotype in humans and animals. We focus in this report on the very likely association between β-amyloid peptide and tau protein in humans and animals with post-isch-emic irreversible neurodegenerative processes and development dementia. It should be emphasized that despite the fact that stroke in humans is one of the main causes of disability, dementia and death in the world, it has no effective therapy improving outcome of the functional and structural irreversible consequences of this disease.