Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (7): 1129-1137.doi: 10.4103/1673-5374.251188

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Exogenous neural stem cell transplantation for cerebral ischemia

Ling-Yi Liao 1 , Benson Wui-Man Lau 2 , Dalinda Isabel Sánchez-Vidaña 2 , Qiang Gao 1, 2   

  1. 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    2 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Qiang Gao, MD, PhD, gaoqiang_hxkf@163.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 0040205401797 (to QG); the General Research Fund of China, No. 15164216 (to BWML).

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Abstract:

Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70–80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effec¬tiveness is narrow. Therefore, the incidence of paralysis, hypoesthesia, aphasia, dysphagia, and cognitive impairment caused by cerebral ischemia is high. Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction. Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue. Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years. This review discusses the treatment of ischemic stroke with neural stem cells, as well as the mechanisms of their involvement in stroke treatment.

Key words: nerve regeneration, stem cell therapy, neural stem cells, cell transplantation, ischemic stroke, cerebral ischemia, neuroplasticity, functional recovery, neural regeneration