Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (8): 1352-1363.doi: 10.4103/1673-5374.253512

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Role and prospects of regenerative biomaterials in the repair of spinal cord injury

Shuo Liu, Yuan-Yuan Xie, Bin Wang   

  1. Clinical Stem Cell Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province,  China
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Bin Wang, MD, wangbin022800@126.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81571213 (to BW), No. 81800583 (to YYX); the 13 th Six Talent Peaks Project (C type) of Jiangsu Province of China (to BW); the Medical Science and Technique Development Foundation of Nanjing of China, No. QRX17006 (to BW); and the Medical Science and Innovation Platform of Nanjing of China, No. ZDX16005 (to BW).

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Abstract:

Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regener¬ation of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some re¬generative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.

Key words: nerve regeneration, spinal cord injury, regenerative biomaterials, scaffolds, tissue engineering, regeneration, transplantation, combination, functional recovery, repair strategy, microenvironment, neural regeneration