Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (8): 1374-1375.doi: 10.4103/1673-5374.253516

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Soluble Neuregulin1 (WRG1): a factor promoting peripheral nerve regeneration by affecting Schwann cell activity immediately after injury

Marwa El Soury, Giovanna Gambarotta   

  1. Department of Clinical and Biological Sciences, University of Torino, Torino , Italyal Model, Institute for Biology II, RWTH Aachen University, Aachen, Germany
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Giovanna Gambarotta, PhD, giovanna.gambarotta@unito.it.

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Abstract:

Neuregulin-1 (NRG1) is a well known growth factor playing contradictory roles in myelination depending on the existing isoform. Transmembrane NRG1 acts as a promyelinating factor, while the soluble isoform inhibits myelination. In this perspective, we would like to emphasize this conflicting role played by NRG1 isoforms regarding their roles in myelination, remyelination and the entire process of peripheral nerve regeneration.