Abstract:

Identification of individuals at risk for developing Alzheimer’s disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity’s peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular. In this perspective, the roles of various genes linked to epileptogenic mechanisms and the risk of AD development are analyzed. We propose that genotyping of apolipoprotein E (APOE) alleles combined with recording of electroencephalogram (EEG) can identify the early-onset AD that will allow highlighting a cohort of individuals at the risk of AD patients.