Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

doi:10.4103/1673-5374.262570

Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (12): 2029-2034.doi: 10.4103/1673-5374.262570

Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

Ignacio Jure ¹ , Alejandro F. De Nicola ^{1, 2} , Florencia Labombarda^{1, 2}

1 Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
2 Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

Online:2019-12-15 Published:2019-12-15
Contact: Florencia Labombarda, PhD,florlabombarda@gmail.com.

Abstract

Abstract:

A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.

Key words: progesterone, progesterone receptor, oligodendrocyte differentiation, myelination, remyelination, neuroinflammation

Ignacio Jure,Alejandro F. De Nicola,Florencia Labombarda. Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor[J]. Neural Regeneration Research, 2019, 14(12): 2029-2034.

[1]	Yu Li, Ping-Ping Shen, Bin Wang. Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy [J]. Neural Regeneration Research, 2021, 16(8): 1500-1509.
[2]	Poornima D. E. Weerasinghe-Mudiyanselage, Jeongtae Kim, Yuna Choi, Changjong Moon, Taekyun Shin, Meejung Ahn. Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury [J]. Neural Regeneration Research, 2021, 16(7): 1331-1335.
[3]	Tianci Chu, Lisa B.E. Shields, Wenxin Zeng, Yi Ping Zhang, Yuanyi Wang, Gregory N. Barnes, Christopher B. Shields, Jun Cai. Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes [J]. Neural Regeneration Research, 2021, 16(7): 1359-1368.
[4]	Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalon. Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease [J]. Neural Regeneration Research, 2021, 16(6): 1099-1104.
[5]	Giuseppe Cappellano, Domizia Vecchio, Luca Magistrelli, Nausicaa Clemente, Davide Raineri, Camilla Barbero Mazzucca, Eleonora Virgilio, Umberto Dianzani, Annalisa Chiocchetti, Cristoforo Comi. The Yin-Yang of osteopontin in nervous system diseases: damage versus repair [J]. Neural Regeneration Research, 2021, 16(6): 1131-1137.
[6]	Mariam Rizk, Justin Vu, Zhi Zhang. Impact of pediatric traumatic brain injury on hippocampal neurogenesis [J]. Neural Regeneration Research, 2021, 16(5): 926-933.
[7]	Francesca Grassivaro, Gianvito Martino, Cinthia Farina. The phenotypic convergence between microglia and peripheral macrophages during development and neuroinflammation paves the way for new therapeutic perspectives [J]. Neural Regeneration Research, 2021, 16(4): 635-637.
[8]	Yuexian Cui, Xuelian Jin, Jun Young Choi, Byung Gon Kim. Modeling subcortical ischemic white matter injury in rodents: unmet need for a breakthrough in translational research [J]. Neural Regeneration Research, 2021, 16(4): 638-642.
[9]	Andis Klegeris. Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns [J]. Neural Regeneration Research, 2021, 16(3): 423-429.
[10]	Ijair R.C. dos Santos, Michelle Nerissa C. Dias, Walace Gomes-Leal. Microglial activation and adult neurogenesis after brain stroke [J]. Neural Regeneration Research, 2021, 16(3): 456-459.
[11]	Alba Guijarro-Belmar, Dominik Mateusz Domanski, Xuenong Bo, Derryck Shewan, Wenlong Huang. The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma [J]. Neural Regeneration Research, 2021, 16(3): 460-469.
[12]	Elliot H. Choi, Chioma Nwakalor, Nolan J. Brown, Joonho Lee, Michael Y. Oh, In Hong Yang. Therapeutic potential of neuromodulation for demyelinating diseases [J]. Neural Regeneration Research, 2021, 16(2): 214-217.
[13]	Marta Sidoryk-Węgrzynowicz, Lidia Strużyńska. Dysfunctional glia: contributors to neurodegenerative disorders [J]. Neural Regeneration Research, 2021, 16(2): 218-222.
[14]	Yu Xu, Ming-Zhu Jin, Ze-Yong Yang, Wei-Lin Jin. Microglia in neurodegenerative diseases [J]. Neural Regeneration Research, 2021, 16(2): 270-280.
[15]	Ulrich Goebel, Stefanie Scheid, Sashko Spassov, Nils Schallner, Jakob Wollborn, Hartmut Buerkle, Felix Ulbrich. Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury [J]. Neural Regeneration Research, 2021, 16(1): 192-198.

Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments