Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (3): 455-456.doi: 10.4103/1673-5374.266054

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Necroptosis in global cerebral ischemia: a role for endoplasmic reticulum stress

Enrique Font-Belmonte1, Paloma González-Rodríguez1, Arsenio Fernández-López1,2   

  1. 1Área de Biología Celular, Instituto de Biomedicina, Universidad de León, León, Spain  2Neural Therapies SL, Edificio Institutos de Investigación, Campus de Vegazana, León, Spain
  • Online:2020-03-15 Published:2020-05-26
  • Contact: Arsenio Fernández-López, PhD, aferl@unileon.es.
  • Supported by:
    This work was supported by MINECO and FEDER funds (RTC-2015- 4094-1); by Junta de Castilla y León (LE025P17); and by Neural therapies SL (NT-Dev-01). Paloma González-Rodríguez is granted from Junta de Castilla y León (EDU/529/2017). Enrique Font-Belmonte is supported by a grant from the University of León.

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Abstract: Necroptosis has been reported in the last years as a type of regulated cell death that can be ignited by a number of specific death receptors, such as FAS, tumor necrosis factor receptor 1 (TNFR1), or pathogen recognition receptors. This cell death subroutine is involved in the response to stress and in homeostatic functions, such as the maintenance of adult T-cell balance (Galluzzi et al., 2018).