Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (10): 1850-1851.doi: 10.4103/1673-5374.280315

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Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease

Eunju Leem1, Sang Ryong Kim1,2   

  1. 1 School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea  2 Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea 
  • Online:2020-10-15 Published:2020-08-18
  • Contact: Sang Ryong Kim, PhD, srk75@knu.ac.kr.
  • Supported by:
    This work was supported by a grant from the National Research Foundation of Korea (NRF-2020R1A2C2007954).

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Abstract: AEG-1, also known as metadherin, was originally identified as a human im- munodeficiency virus-1- and tumor necrosis factor-alpha-inducible gene in human fetal astrocytes. The increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer, and its upregulation triggers evasion of cellular apoptosis, metastasis, and invasion in cancer (Emdad at al., 2016; Dhiman et al., 2019). AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathways, contributing to an invasive phenotype and angiogenesis (Emdad at al., 2016; Dhiman et al., 2019). In addition, there is evi- dence for a functional link between AEG-1 and pro-survival mech- anisms in various cancers (Dhiman et al., 2019), suggesting that AEG-1 is a key molecule for oncogenic events in cancer.