Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (11): 2008-2015.doi: 10.4103/1673-5374.282240

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Neuroprotection mediated by natural products and their chemical derivatives

Fei Fei1, Ning Su2, Xia Li3, Zhou Fei3   

  1. 1 Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi’an, Shaanxi Province, China
    2 Department of Radiation Oncology, Xijing Hospital, the Fourth Military Medical University, Xi’an, Shaanxi Province, China
    3 Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi’an, Shaanxi Province, China
  • Online:2020-11-15 Published:2020-08-04
  • Contact: Xia Li, MD, PhD,sjwklixia@sina.com.cn; Zhou Fei, MD, PhD,feizhou@fmmu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 81600738 (to FF), 81771239 (to ZF), 81430043 (to ZF), 81801300 (to NS).

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Abstract: Neuronal injuries can lead to various diseases such as neurodegenerative diseases, stroke, trauma, ischemia and, more specifically, glaucoma and optic neuritis. The cellular mechanisms that regulate neuronal death include calcium influx and calcium overload, excitatory amino acid release, oxidative stress, inflammation and microglial activation. Much attention has been paid to the effective prevention and treatment of neuroprotective drugs by natural products. This review summarizes the neuroprotective aspects of natural products, extracted from Panax ginseng, Camellia sinensis, soy and some other plants, and some of their chemical derivatives. Their antioxidative and anti-inflammatory action and their inhibition of apoptosis and microglial activation are assessed. This will provide new directions for the development of novel drugs and strategies to treat neurodegenerative diseases.

Key words: antioxidant effect, brain injuries, Camellia sinensis, chemical derivatives, curcumin, genistein, natural products, neurodegenerative diseases, neuroprotection, Panax