Neural Regeneration Research ›› 2020, Vol. 15 ›› Issue (11): 2089-2097.doi: 10.4103/1673-5374.282269

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Research hotspots and effectiveness of repetitive transcranial magnetic stimulation in stroke rehabilitation

Ai-Hua Xu, Yong-Xin Sun   

  1. Department of Rehabilitation Medicine, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
  • Online:2020-11-15 Published:2020-08-23
  • Contact: Yong-Xin Sun,sunyongxin@cmu.edu.cn.

Abstract: Repetitive transcranial magnetic stimulation, as a relatively new type of rehabilitation treatment, is a pain- less and non-invasive method for altering brain excitability. Repetitive transcranial magnetic stimulation has been widely used in the neurorehabilitation of stroke patients. Here, we used CiteSpace software to visually analyze 315 studies concerning repetitive transcranial magnetic stimulation for stroke rehabili- tation from 1999 to 2019, indexed by Web of Science, to clarify the research hotspots in different periods and characterize the gradual process of discovery in this field. We found that four main points were gen- erally accepted: (1) repetitive transcranial magnetic stimulation has a positive effect on motor function recovery in patients with subcortical stroke; (2) it may be more advantageous for stroke patients to receive low-frequency repetitive transcranial magnetic stimulation in the unaffected hemispheres than to receive high-frequency repetitive transcranial magnetic stimulation in affected hemisphere; (3) low-frequency repetitive transcranial magnetic stimulation has become a potential therapeutic tool for patients with non-fluent aphasia after chronic stroke for neurological rehabilitation and language recovery; and (4) there are some limitations to these classic clinical studies, such as small sample size and low test efficiency. Our assessment indicates that prospective, multi-center, large-sample, randomized controlled clinical trials are still needed to further verify the effectiveness of various repetitive transcranial magnetic stimulation pro- grams for the rehabilitation of stroke patients.

Key words: data visualization, motor recovery, rehabilitation, repetitive transcranial magnetic stimulation, stroke, stroke rehabilitation, transcranial magnetic stimulation