Abstract: Dementia is a progressive cognitive impairment that affects the activities of daily living. Alzheimer’s disease (AD) is the most common form of the dementia worldwide accounting for 60–80% of all dementia cases. With an estimated cost exceeding $290 billion in the USA, understanding and devel- opment of future therapeutic strategies is vital. In this perspective, we will be examining the current thinking of AD research and therapeutic strate- gies, while proposing a possible new direction for diagnosis, understanding, and treatment targets. Non-coding RNA accounts for the largest popu- lation of the human transcriptome. Long noncoding RNA (lncRNA) is a recent molecule of interest in the biomedical research which is non protein coding and is of length greater than 200 nucleotides. LncRNAs have been shown to play diverse roles within the cells such as posttranscriptional and posttranslational regulation, chromatin modulation, and protein complex organization. Given the fexible and diverse role in disease pathophysiology, lncRNAs may serve as novel therapeutic targets for diagnosis and treatment. Evidently, recent studies showed that dysregulation of lncRNA infuences the clinical course of tumorigenesis, neurological disorders, cardiovascular disease, diabetes, and acquired immunodefciency syndrome (Kazimierczyk et al., 2020). Tis indicates that lncRNA can provide a unique avenue of re- search and possible therapeutic targets in AD.