Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (1): 108-109.doi: 10.4103/1673-5374.286962

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cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes

Keun-Young Kim, Won-Kyu Ju*   

  1. National Center for Microscopy and Imaging Research and Department of Neurosciences, University of California San Diego, La Jolla, CA, USA (Kim KY)
    Hamilton Glaucoma Center and Shiley Eye Institute, The Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA (Ju WK)
  • Online:2021-01-15 Published:2020-11-25
  • Contact: Won-Kyu Ju, PhD, wju@ucsd.edu.

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Abstract: Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older. Despite the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head (ONH) that is associated with retinal ganglion cell (RGC) axon degeneration, the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly understood. Oxidative stress is strongly linked to glaucoma pathogenesis, and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.