Abstract: Extract from the medicinal herb Withania somnifera (WS), commonly known as Ashwagandha, has therapeutic implications in various conditions such as infection, inflammation, cancer, stress, neurodegenerative diseases, heart disease, diabetes, and others. Withaferin A (WA), a relatively nontoxic steroidal lactone isolated from WS extract, has often been tested for its anti-tumor properties (Dar et al., 2015; Marlow et al., 2017). It has been demonstrated that WA may also serve as a neuroprotectant in a number of neurological conditions, including Parkinson’s disease (PD), cerebral infarctions (CI), reactive gliosis, amyotrophic lateral sclerosis (ALS), and human immunodeficiency virus-associated neurological dysfunctions (HIV-AND).