Abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) that has both inflammatory and neurodegenerative components. Both genetic and environmental factors confer risk for developing the disease. Additionally, gut microbiota appears to play an important role in the risk for MS and potentially also in affecting disease severity, though our understanding of these interactions are still incomplete (Bhargava and Mowry, 2014). The circulating metabolome is at the intersection of these various factors – genome, gut microbiome and exposome and provides unique insights into the pathophysiology of the disease (Bhargava and Anthony, 2020).