Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (3): 512-513.doi: 10.4103/1673-5374.293148

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Psychosis symptoms following aberrant immunity in the brain

Akitoshi Ozaki#, Yuki Yamawaki#, Gen Ohtsuki*   

  1. Department of Biophysics, Kyoto University Graduate School of Science, Kyoto, Japan (Ozaki A, Ohtsuki G)
    The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan (Ohtsuki G)
    Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (Yamawaki Y, Ohtsuki G)
  • Online:2021-03-15 Published:2020-12-17
  • Contact: Gen Ohtsuki, PhD,ohtsuki.gen.7w@kyoto-u.ac.jp.
  • Supported by:
    We would like to present our deep appreciation to Profs. Christian Hansel, Tomoo Hirano, and Shu Narumiya for supports on the research. We thank Nao Katsurada for invaluable comments on the manuscript. 
    This work was supported by grants from the Kowa Life Science Foundation, the Japanese Society for Promotion of Science (KAKENHI, Grant-in-Aid for Young Scientists (A) 26710002), the Brain Science Foundation, the Tokyo Biochemical Research Foundation, the Naito Foundation, and the Hakubi-project grant (Kyoto University) (all to GO).

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Abstract: Neuroinflammation in the brain is thought related to the emergence of various psychoses, although the identifying regional significance, the involvement of immune-cells and lymphocytic activity, and ways for the therapeutic recovery are under the effort of researchers. We recently revealed that the cerebellar acute inflammation causes the symptoms manifested in mood disorders or developmental disorders, which were associated with hyperexcitability due to immune-triggered plasticity and the overconnectivity between the inflamed cerebellum and prefrontal cortex (Yamamoto et al., 2019). Here, we give a perspective regarding the emergence of psychoses focusing on the aberrant immunity, the relevance of dysfunctions in brain regions including the cerebellum, and potential therapeutic ways via metabolism.