Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (4): 686-687.doi: 10.4103/1673-5374.295331

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Mitochondrial bioenergetics and neurodegeneration: a paso doble

Alice Rossi*, Paola Pizzo*   

  1. Department of Biomedical Sciences, University of Padua, Padua, Italy (Rossi A, Pizzo P)
    Department of Neuroscience, Max-Delbruck Centrum fur Molekulare Medizin, Berlin, Germany  (Rossi A)
    Neuroscience Institute – Italian National Research Council (CNR), Padua, Italy (Pizzo P)
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Paola Pizzo, PhD, paola.pizzo@unipd.it; Alice Rossi, PhD, Alice.Rossi@mdc-berlin.de.
  • Supported by:
    The authors would like to thank R. Filadi for the reading of the manuscript and the helpful discussion.

    This work was supported by the Italian Ministry of University and Scientific Research (PRIN 2017), the University of Padua (SID 2019), the UNIPD Funds for Research Equipment (2015). 

    Data of the original article (Rossi et al., 2020 Cell Reports) have been presented at the European Calcium Society (ECS) Workshop 2019 in Coimbra, Portugal and at the EMBO/India Symposium 2020 in Bangalore, India. 

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Abstract: The brain is one of the highest energy demanding organs, consuming ~20% of the total ATP produced by the whole body. Importantly, neurons mainly rely on ATP synthesized by mitochondrial bioenergetics and neuronal activity is strictly dependent on specific mitochondrial localization at synapses, sites consuming a high amount of energy requested for both pre- and post-synaptic processes. Here, mitochondria produce ATP and buffer Ca2+ rises, two essential processes for neurotransmission and generation of membrane potential along the axon (Magistretti and Allaman, 2015).