Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (5): 999-1000.doi: 10.4103/1673-5374.297065

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Organotypic hippocampal slices, an emerging tool to model synucleinopathies

Sara Elfarrash, Poul Henning Jensen*    

  1. Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt (Elfarrash S)
    DANDRITE‑Danish Research Institute of Translational Neuroscience and Department of Biomedicine, Aarhus University, Aarhus, Denmark (Jensen PH)
  • Online:2021-05-15 Published:2020-12-29
  • Contact: Poul Henning Jensen, PhD,phj@biomed.au.dk.
  • Supported by:
    This work was supported by the Lundbeck Foundation grants R248-2016-2518 for Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, and R223-2015-4222, Michael J Fox Foundation grant 12028.01, Cultural Affairs and Mission Sector, Ministry of Higher Education, Arab Republic of Egypt.

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Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. PD has been traditionally considered a motoric disorder characterized by tremor, rigidity and bradykinesia, however it is now settled that PD also comprises a range of non-motor symptoms like hyposmia, sleep disturbances and cognitive impairments (Tysnes and Storstein, 2017).