Abstract: Microvascular dysfunction has been implicated in many diseases such as stroke and diabetes. In addition to the microvascular endothelial cell (EC), the pericyte, a perivascular cell that adheres to the abluminal side of the EC may also be important to ensure proper microvascular function. As a prominent perivascular cell, the pericyte has garnered increasing attention for its multiple functional aspects, especially the pericyte of central nervous system (Yemisci et al., 2009; Armulik et al., 2010; Gaceb et al., 2018). The integrity of the blood-brain barrier (BBB), regulation of cerebral blood flow, and proper functioning of the glymphatic and immune defense systems may all be dependent on the coordination between brain pericytes and their neighboring cells (Yemisci et al., 2009; Armulik et al., 2010; Gaceb et al., 2018). Since the brain communicates with all peripheral organs, pericyte dysfunction in brain and in peripheral organs may, respectively, adversely impact peripheral organs and brain. Thus, pericyte behavior may provide potential links in the communication axis of brain and peripheral organs. In this perspective, we discuss associations of pericyte functions and pathologies between brain and selective peripheral organs, and elucidation of which may lead to novel therapeutic applications.