Abstract: Neural stem/precursor cells (NSPCs) hold great promise in improving central nervous system (CNS) repair, either by triggering endogenous NSPC sources of the CNS or by transplantation of NSPCs. The molecular mechanisms of NSPC survival and integration as well as their cell fate determination are still insufficiently understood, yet will be instrumental for harnessing these cells for brain repair. In our recent Nature Communications manuscript entitled “Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling” (Pous et al., 2020), we advanced towards understanding how CNS disease alters the brain subventricular zone (SVZ) stem cell niche environment by the disease-triggered deposition of blood-derived factors and how these factors regulate NSPC fate and brain repair. Here, we summarize the relevance of our original findings for NSPC biology in CNS disease, its possible implications for other CNS stem cell niches and other CNS diseases. Also, we discuss how current knowledge can be applied to control NSPC fate and functions tailored to promote CNS repair.