Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (7): 1409-1410.doi: 10.4103/1673-5374.301010

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Application of flavonoids for the protection of nigral dopaminergic neurons from oxidative stress

Sang Ryong Kim*   

  1. School of Life Sciences, BK21 plus KNU Creative BioResearch Group; Institute of Life Science & Biotechnology; Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea
  • Online:2021-07-15 Published:2021-01-07
  • Contact: Sang Ryong Kim, PhD, srk75@knu.ac.kr.
  • Supported by:
    This work was supported by a grant from the National Research Foundation of Korea, No. NRF-2020R1A2C2007954 (to SRK).

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Abstract: Oxidative stress in Parkinson’s disease (PD): Oxidative stress is the imbalance between oxidants, which generate reactive oxygen species (ROS; free radicals), and antioxidants, which remove free radicals. Under healthy conditions, the levels of oxidants and antioxidants are well-balanced. However, excessive production of ROS and a deficiency of antioxidants leads to oxidative stress, which may be the cause of accelerating the development of neurodegenerative diseases (Hwang, 2013), suggesting that the prevention of ROS production and reduction of oxidative stress is critical for both the prevention and treatment of neurodegenerative diseases, including PD.