Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (8): 1554-1555.doi: 10.4103/1673-5374.303017

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Application of PROTAC strategy to TTR-Aβ protein-protein interaction for the development of Alzheimer’s disease drugs

Nicoló Tonali, Susanna Nencetti, Elisabetta Orlandini, Lidia Ciccone*   

  1. Université Paris-Saclay, CNRS, BioCIS, 
    Châtenay-Malabry, France (Tonali N)
    Department of Pharmacy, University of Pisa, Pisa, Italy (Nencetti S, Ciccone L)
    Department of Earth Sciences, Research Center “E. Piaggio”, University of Pisa, Pisa, Italy (Orlandini E)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Lidia Ciccone, lidia.ciccone@unipi.it.
  • Supported by:
    We thank Italian Ministero dell’Istruzione, dell’Universitá e della Ricerca (PRIN 2017SNRXH3) and PRA_2018_20 Approcci Target/Multitarget per il disegno e lo sviluppo di Small Molecules per terapie innovative. 

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Abstract: Alzheimer’s disease (AD) is a complex and multifaced neurodegenerative disorder for which the precise pathological molecular mechanisms are still not completely known.