Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (8): 1546-1547.doi: 10.4103/1673-5374.303019

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Stem cell-derived three-dimensional (organoid) models of Alzheimer’s disease: a precision medicine approach

Sujung Jun Kim, Jiaxin Li, Vasiliki Mahairaki*   

  1. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA (Kim SJ, Li J, Mahairaki V)
    Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA (Kim SJ) 
    The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease, Johns Hopkins Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA (Mahairaki V)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Vasiliki Mahairaki, vmachai1@jhmi.edu.
  • Supported by:
    The work was supported by the grant from the Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease at Johns Hopkins. 

Abstract: The major challenges of the “brain disorders” field – dementia, schizophrenia, other neuropsychiatric disorders – are that these are defined by clinical phenotypes whose underlying biology is poorly understood. There is great variability in definition, prognosis, trajectory, and treatment response indicating that the next step is defining subgroups by combining clinical and biologic information at the level of the individual. These challenges are especially relevant and urgent in the case of dementia and related disorders.