Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (8): 1537-1538.doi: 10.4103/1673-5374.303022

Previous Articles     Next Articles

Role of dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans’ nervous system under hypoxia

Leonardo Hernandez*, Gabriela Camargo   

  1. Departamento de Fisiología. CUCS-Universidad de Guadalajara, Guadalajara, Jalisco, Mexico (Hernandez L) 
    Departamento de Ciencias de la Salud. CUALTOS-Universidad de Guadalajara, Tepatitlan, Jalisco, Mexico (Camargo G)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Leonardo Hernandez, PhD,leonardo.hhernandez@academicos.udg.mx or leohhdez@hotmail.com.

Abstract: In nature, changes in O2 levels occur frequently. An inadequate supply of oxygen often happens in living systems, which induces an imbalance between oxygen entering cells and their oxygen demand to produce energy. The condition is known as hypoxia. Although hypoxia takes place in multiple physiological processes, it can be a primary cause of cellular injury and death (Nystul and Roth, 2004). Consequently, cells and tissues are habitually at risk, and they have developed many strategies to cope with low oxygen levels leading to pathological conditions (Fawcett et al., 2015). These adaptative responses to hypoxia though not entirely understood, seem to be evolutively conserved. Notwithstanding these responses, hypoxia can still have harmful effects.