Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (8): 1548-1549.doi: 10.4103/1673-5374.303023

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Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer’s disease

Marcus Augusto-Oliveira*, Alexei Verkhratsky*   

  1. Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, 66075-110 Belém, Brasil (Augusto-Oliveira M)
    Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK (Verkhratsky A)
    Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain & Department of Neurosciences, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain (Verkhratsky A)
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Marcus Augusto-Oliveira, PhD, marcusadeoliveira@outlook.com; Alexei Verkhratsky, MD, PhD, DSc, Alexej.Verkhratsky@manchester.ac.uk.
  • Supported by:
    MAO was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, grant No. 27724/2018-2) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, grant No. 88887.2005.00/2018-00). 

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Abstract: Alzheimer`s disease (AD) is the widespread and the most feared neurodegenerative disorder leading to dementia in the elderly. AD, by eliminating intelligence, diminishes a man to helpless body, places an unbearable strain on patients, families, and fuels socio-economic healthcare crises around the world. The main histopathological hallmarks of AD are the accumulation of extracellular amyloid depositions known as senile plaques and intracellular neurofibrillary tangles, together with severe dysfunctional synaptic connectivity and neuronal death leading to brain atrophy.