Abstract: Alzheimer’s disease (AD) has a multifactorial etiology that has eluded scientists and clinicians for decades. This incomplete understanding of the causal factors likely contributes to the dearth of effective therapeutics available to treat this growing pandemic. Cholinesterase inhibitors such as galantamine, rivastigmine and donepezil are considered frontline treatments but these medications merely treat some of the symptoms associated with AD, rather than curing or even slowing the progression of the disease. This has caused some investigators and clinicians to start exploring the potential to prevent AD. However, the concept of AD has gained widespread acceptance in the clinical community, with many stating that the prevention of AD is impossible. While we would concede that reducing the likelihood of AD development to zero is impossible, these authors argue that significant reduction of the risk of developing AD, particularly in patients at an elevated risk for AD development, is achievable today, and can save many lives and life years.