Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (10): 2002-2003.doi: 10.4103/1673-5374.308094

Previous Articles     Next Articles

OTX2 signaling in retinal dysfunction, degeneration and regeneration

Kenneth. L. Moya*, Raoul Torero Ibad*   

  1. Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France (Moya KL, Ibad RT)
    Univ. Lille, CNRS, UMR 8523 -PhLAM -Physique des Lasers Atomes et Molécules, F-59000 Lille, France (Ibad RT)
  • Online:2021-10-15 Published:2021-03-19
  • Contact: Kenneth. L. Moya, PhD, ken.moya@college-de-france.fr; Raoul Torero Ibad, PhD, raoul.torero@univ-lille.fr.
  • Supported by:
    We thank France Maloumian of the Collège de France (Paris, France) for graphic illustration.

    KLM is a coinventor for the use of OTX2 in eye disease and a cofounder of BrainEver.

    This work was supported by HOMEOSIGN: ERC-2013-AdG n°339379 and NeuroprOtx: ANR-16-CE16-0003-02.

PDF

92

Abstract: The protein OTX2 in the retina is necessary for the maintenance of normal physiologic processes, and may be a promising therapeutic agent for some ophthalmic diseases. In this Perspective, we first shortly introduce the organization of the retina and the importance of OTX2 expression. We then present an example of reduced OTX2 activity in the developed retina associated with structural and functional consequences. We next show that homeoproteins can have neuroprotective functions. We finally review several clear examples of OTX2 non-cell autonomous activity in the retina and the effects of diminishing or providing extracellular OTX2.