Abstract: Neural stem cells (NSCs) are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal, astroglial, and oligodendroglial lineages, in defined processes termed neurogenesis, astrogliogenesis and oligodendrogenesis, respectively (reviewed in Braun and Jessberger, 2014). During brain development, NSCs are present throughout the brain, becoming progressively restricted to defined brain regions. In the adult brain, NSCs are mainly present in areas classically known as neurogenic niches, i.e. the subventricular zone (SVZ), along the lateral walls of the lateral ventricles, and the subgranular zone, located in the dentate gyrus (DG) of the hippocampus. These areas are particularly enriched with NSCs, which not only are multipotent cells but also proliferative cells with the ability to self-renew, thus maintaining their own pool of cells. In fact, neurogenesis, astrogliogenesis and oligodendrogenesis are highly intricate processes comprising several steps, including proliferation, differentiation, migration, and functional integration of the newly formed cells in the existing circuitry, which are regulated by a plethora of factors. These newly differentiated adult-born cells have the capacity to continuously modulate brain function and plasticity, by constantly reacting to external or internal stimuli (reviewed in Braun and Jessberger, 2014).