Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (11): 2222-2224.doi: 10.4103/1673-5374.310679

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Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay

Giuseppe Arena, Nazanine Modjtahedi, Rejko Kruger#br#   

  1. Translational Neuroscience group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg (Arena G, Kruger R)
    Université Paris-Saclay, Gustave Roussy Institute, CNRS, Metabolic and systemic aspects of oncogenesis for new therapeutic approaches, Villejuif, France (Modjtahedi N)
    Parkinson Research Clinic, Centre Hospitalier du Luxembourg (CHL), Esch-sur-Alzette, Luxembourg (Kruger R)
    Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg (Kruger R)
  • Online:2021-11-15 Published:2021-04-13
  • Contact: Giuseppe Arena, PhD, giuseppe.arena@uni.lu.
  • Supported by:
    This work was supported by grants from the Luxembourg National Research Fund (FNR) for the National Centre for Excellence in Research on Parkinson’s disease (NCER-PD to RK), the PEARL program (FNR/P13/6682797 to RK) and MiRisk‐PD (C17/BM/11676395 to RK and GA). RK has also received research grants from the Michael J Fox Foundation, the European Union’s Joint Program-Neurodegenerative Diseases (JPND; COURAGE-PD), the European Union’s Horizon2020 research and innovation program (No. 692320), and the Federal Ministry for Education and Research (BMBF; Mito-PD 031 A 430 A). NM was supported by the French National Cancer Institute (INCA2017-1-PLBIO-08) and by Fondation pour la recherche contre le cancer (ARC). 

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Abstract: Parkinson’s disease (PD) is a common movement disorder of the elderly caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the brain.