Abstract: Increased occurrence of age-associated disabilities and neurodegenerative diseases is the price we pay for the tremendous elevation in life expectancy in our modern society. Aging comes along with structural, neurochemical and physiological alterations in the brain that cause memory decline and cognitive impairments (Rozycka and Liguz-Lecznar, 2017). Numerous factors contribute to cognitive aging including hormonal, metabolic, and immune dysregulation, elevated oxidative stress and inflammation, changes in neurotransmission, and diminished neurotrophic support of neurons (Rozycka and Liguz-Lecznar, 2017). Thereby, different brain regions and neuronal cell types are distinctively affected by the process of aging. Apart from reduced excitability and plasticity, the decline in inhibitory function represents a prominent feature of aged brains (Zimmer-Bensch, 2019a). A selective vulnerability of inhibitory interneurons and GABAergic (gamma-aminobutyric acid) synapses is reported for diverse regions of the aged brain across different species. This is reflected by reduced numbers of inhibitory cortical interneuron subtypes, as well as by functional and structural changes of GABAergic synapses (Rozycka and Liguz-Lecznar, 2017; Zimmer-Bensch, 2019a).