Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 323-324.doi: 10.4103/1673-5374.317973

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Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts

Ming-Yue Wu#, Cui-Zan Cai#, Chuanbin Yang, Zhenyu Yue, Ye Chen, ZhaoXiang Bian, Min Li*, Jia-Hong Lu*#br#   

  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, China (Wu MY, Cai CZ, 
    Lu JH)
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, China (Yang C, Bian ZX, Li M)
    Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA (Yue Z)
    Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China (Chen Y)
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Jia-Hong Lu, PhD, jiahonglu@um.edu.mo; Min Li, PhD, limin@hkbu.edu.hk.
  • Supported by:
    This work was supported by the China Ministry of Science and Technology grant (No. MoST-2017YFE0120100), The Science and Technology Development Fund, Macau SAR (Nos. 024/2017/AMJ, 0128/2019/A3), and the University of Macau grant (No. MYRG2019-00129-ICMS) (to JHL). This work was also supported by GRF/HKBU (Nos. 12101417, 12100618) and HMRF (Nos. 17182541, 17182551) (to ML).

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Abstract: NRBF2 has been identified as the fifth component of PI3KC3 complex and is required for maintaining the kinase activity to promote autophagy. However, the physiological and pathological roles of NRBF2 are largely unknown. In our recent studies, we have revealed that NRBF2 plays an important role in preventing the Alzheimer’s disease (AD) and inflammatory bowel disease (IBD) development, via the mechanisms involving regulating autophagosome maturation and phagosome maturation. The findings expand our understanding towards the physiological role of PI3KC3 complex and provide a potential strategy for AD and IBD treatment by regulating PI3KC3 complex activity.